SAM-e S-adenosylmethionine, or SAM-e for short, is one of the few nutritional supplements that has good clinical research to support its safety and effectiveness. Although SAM-e is used for many purposes, we are particularly interested in it as a compound that may have antidepressant properties. Clinical Significance S-adenosylmethionine (SAMe) is involved in many reactions that involve methylating chemicals (transferring a methyl …