Methylfolate is the active form of folic acid – which is an essential B vitamin. Methylfolate is essential for the brain to make the neurotransmitters that prevent depression (norepinephrine, serotonin, and dopamine). In other words, a low level of depression can cause or worsen depression because it leads to lower levels of serotonin, norepinephrine and dopamine. Most of us are able to get plenty …