A very talented writer who we’ve been seeing for about six months has noticed that her creativity seems to be way down. Creativity is a fundamental part of her view of herself. She is very upset. Her concern is that the lithium she has been taking might be the cause. However, she has been quite depressed for the last month. What …
Cognition Enhancing Apps
An experimental computer program is associated with improved attention and working memory in people over age 60, even 6 months after training. Somewhat fuzzy-brained after a poor night of sleep I ran across this summary of a paper that was just published in the prestigious scientific journal Nature (Anguera JA et al., Nature 2013 Sep 5; 501:97). Where could I test drive this application, …
Depression and Inflammation
Recently there has been increasing interest in the relationship between depression and chronic overactivity of the body’s biological defense system – inflammation. When we have an infection, or an injury, or almost any other kind of illness, the body activates a series of processes designed to respond to the threat. Unfortunately, the inflammation system, especially if it is turned on …
My Brain Isn’t Working
Difficulties with cognition and focus are almost universal in folks with moods. In the scientific literature there have been attempts to distinguish between mood related problems and problems that tend to persist regardless of mood state. There is probably nothing that can more profoundly affect our brain’s ability to focus than an episode of depression or mania. These functional brain …
Antidepressants Help You Focus on the Positive
I am always interested in articles that help us understand how medications work, and perhaps how the brain functions in different mood states. Today I got a copy of a pre-publication article from the American Journal of Psychiatry that confirms other research about antidepressants – antidepressants work, at least in part, by helping us to shift from negative information to positive …
Hormones and Food
In an earlier post we talked about some of the research on appetite. We reviewed some of the peptide hormones that regulate appetite and how the entire system that controls appetite is really designed to cope better with a time of scarcity than a time of plenty. Here I want to talk more specifically about the interplay between other hormone …
Dual Treatment: Medications and Therapy Work Together to Treat Depression
A review in the prestigious journal JAMA Psychiatry suggests that there may be a clear biological explanation of how medications and psychotherapy work together to treat depression. The authors note that recent, unexpected, research findings suggest that antidepressant medications reactivate the brain’s ability to relearn old lessons. The medications allow the brain to modify old neuron connections in a way …
Therapy or Medications for Depression?
A new study published in the most prestigious psychiatric journal (JAMA Psychiatry – see reference below) strongly suggests that a brain scan might be able to help people decide whether therapy or medications are more likely to treat their depression. As background, although some people feel that for more severe depression medications are more effective, the fact is that most …
Brain Scan Diagnosis?
A newly developed brain scanning method that measures blood flow to different parts of the brain may help to distinguish between bipolar and unipolar depression, according to a study that got a fair amount of media attention. The study of 54 adult women used a novel way of measuring brain function called arterial spin labeling (ASL). This approach allowed much …
Childhood Trauma – Brain Effects
Experiencing trauma in childhood is associated with changes in the brain during teenage years, according to a study of 117 adolescents using magnetic resonance imaging (MRI). The researchers compared MRI’s from age 12 with MRI’s from age 16. They asked the teenagers about childhood trauma and also did psychiatric diagnostic interviews. There were significant differences in how the brains of teenagers …
Hunger Regulation
Recently several folks have asked us questions about diet, hunger, weight gain, and nutrition. Certainly for many people with depression, gaining weight is an important issue, both as a cause and consequence of depression. Let’s begin by trying to make some sense of hunger. In other posts we will be talking about how stress and the hormone system relates to …
Ginseng
If you are a ginseng believer, then ginseng is the one supplement that all of us should be taking. Russian scientist Israel Brekhman coined the term “adoptegens” to refer to agents that helped individuals deal with stress. The prime example of this, in his view, was ginseng. [If you are interested in an example of the controversy that surrounds many …
Memory, Stress and Aging
Many older people are concerned about impaired memory, and the relationship between memory, stress, and aging can be difficult to untangle. Obviously worry about memory problems can be a source of anxiety and stress. But can stress and anxiety be a cause of memory problems? And if so what can be done about it? Elsewhere we will be talking about …
Emotion Regulation and Bipolar
Researchers from the University of Mannheim investigated brain activity in people at increased risk of bipolar disorder to see if there was something about how these people handled negative emotions that might them be at increased risk of mood cycles. They used a powerful brain imaging technique called functional magnetic resonance imaging that allows researchers to see which parts of the …
Life Energy
Freud came up with the term libido to describe the sum of all the human instincts related to love. In his view, there was a limited amount of this libidinal energy and it was important to use it wisely. Invest it in the wrong activities and you could end up with nothing to show for it. This notion of limits …
Mood and the Brain’s Clock
As we slowly move from summer to fall, it may be timely that the issue of Biological Psychiatry that arrived in the mail today is devoted to how the brain’s clock affects mood. It points to growing evidence that part of what drives mood cycles are disruptions in the brain’s daily (circadian) rhythms. It appears that people who are vulnerable …
Selective Attention
One morning, while I was riding a bike, I got to thinking about how mood affects attention and how that, in turn, creates a different reality for us depending on what mood we’re in. To think all these thoughts were sparked by my reaction to the image of a dead squirrel… Several weeks ago, it had been an especially dark …
Depressed Mothers and Oxytocin
Oxytocin is often brought up in conversations about childbirth. After childbirth, new mothers normally experience surges of oxytocin that increase feelings of maternal bonding, trust, and empathy. In addition to facilitating pair bonding, recent studies have shown oxytocin plays a greater role in mental health than originally thought. Low levels of oxytocin may be a phenomenon linked to depression. Maternal …
Brain Power
Problems with memory are common for people with depression (and the rest of us, as we age, as well). Although the most important thing to do to improve brain function is to address mood extremes, there are often residual problems, and sometimes there are negative brain effects from the medications that help stabilize mood. A wonderful older man who came …
Coming Home
Where does the mind go when it is not occupied by the worries, frustration, and anxiety? Does it go to a happy place, or are people naturally angry? According to Rick Hanson, PhD, the mind constantly fluctuates between a reactive and responsive state. When in the responsive state, the body is able to relax and reenergize. It is a time …